Objective To retrospectively summarize the clinical features and imaging characteristics of 46 cases with pituitary adenomas. Methods Forty-six cases with pituitary adenomas treated in our hospital between February 2013 and February 2016 were retrospectively analyzed. The age of onset, gender, clinical manifestations, type, size and shape of pituitary adenomas were summarized. The CT and MRI imaging manifestations of pituitary adenomas were analyzed, and the characteristics of CT plain scan, enhanced scan, MRI scan and enhanced scan were summarized. Results Most of the patients with pituitary adenoma were female, and the age of onset was significantly smaller than that of the male patients. The main clinical manifestations included dizziness, vomiting, blurred or declined vision, galactorrhea, amenorrhea and menstrual disorders. In various types of pituitary adenomas, prolactinoma, mixed tumor and ACTH adenomas were common. The detection of micro-adenoma is difficult, and most of them were equal density or low density lesions. Enhanced early pituitary gland showed a limited low density area, with clear boundary; CT plain scanning of large adenomas showed supra sella cistern hemorrhage, with complete capsule and clear boundary, showing homogeneous density or slightly higher density region. The TIWI of micro-adenomas and large adenomas showed low signal or slightly low signal, and T2WI showed high or equal signal; Enhanced scan showed limited low density region, with clear boundary. Conclusion Pituitary adenomas have certain clinical features and they easily occur in women of reproductive age. Most of them are macroadenomas. Patients have dizziness, vomiting, blurred or declined vision, galactorrhea, amenorrhea, menstrual disorders and other symptoms. CT and MRI imaging manifestations of pituitary adenomas have certain characteristics, which can well display necrosis, cystic change and hemorrhage. Both of the two methods are feasible for clinical examination of adenomas.