Objective To explore the application on the liver function Child-Pugh classification for the patients with cirrhosis of liver by CT liver volume measurement techniques. Methods 85 cases of patients with cirrhosis of liver were divided into group A(30 cases), group B(29 cases) and group C(26 cases) according to liver function ChildPugh classification. 60 cases of healthy person were researched as the control group. The volume in each region of the liver, different Child - Pugh, hierarchical volume in patients with liver cirrhosis, healthy liver volume difference between different age were compared. Results The left lateral external lobe of liver, caudate lobe for the patients with cirrhosis of liver were higher than the control group(P<0.05). The left lobe, right anterior lobe, right rear leaf and total volume for the patients with cirrhosis of liver were lower than the control group(P<0.05). The Child - Pugh, classification of patients with liver cirrhosis liver volume was significantly decreasing trend(P<0.05); The liver volume was significantly decreasing trend along with the age growth(P<0.05). Conclusion It negative correlations patients with cirrhosis liver volume shrink degree and Child-Pugh, it has important reference value CT of the liver volume measurement of liver function in patients with Child-Pugh.