Objective Scientific research of multislice spiral CT angiography 3D reconstruction technology application in the diagnosis of cerebral vascular diseases, for the treatment of patients with cerebral vascular disease to provide scientific reference data. Methods Using retrospective method, selected in our hospital from August 2015 - 2016 February were cerebral vascular lesions in patients with clinical data of 35 cases as the research object, the application of multislice spiral CT angiography for examination, using spss20.0 statistical software for statistical analysis after the application of multi-slice spiral CT angiography in workstation for 3D reconstruction and analysis of the anatomical relationship of patients with vascular lesions of the brain. Results 35 cases of patients with cerebral vascular disease in 19 patients with aneurysm patients, 10 cases of dynamic venous malformation patients, 2 cases of cerebral vascular stenosis in patients with, 4 cases of embryonic brain aneurysm (congenital dysplasia) patients, each set of data comparisons were statistically significant (P<0.05), 35 cases of patients with cerebral vascular disease of multislice spiral CT angiography showed clear, to observe the size and shape of the specific location of the aneurysm, after pathological examination is not difficult to find 31 of 35 cases of patients with cerebral vascular disease in positive cases, positive rate was 88.57%. Conclusion Multi-slice spiral CT angiography (made image three-dimensional reconstruction techniques used in The diagnostic effect of cerebral vascular disease is more significant.