Objective To investigate the clinical value of CT dynamic enhancement and MRI in the diagnosis of liver abscess. Methods Retrospective analysis of the general clinical data and imaging data of 81 patients with liver abscess confirmed by surgery and pathology in our hospital from August 2013 to December 2015. Observation and comparison of CT dynamic enhanced scan and MRI scan imaging features of liver abscess. Summary and analysis of the pathological stage, etiology, scope, form and strengthening methods are summarized and analyzed. Results In this group, 81 cases were solitary in 67 cases and multiple in 14 cases. The abscess was located in the right lobe of the liver in 49 cases, the left lobe of the liver in 25 cases, and the left and right liver in 7 cases. The diameter of the abscess was between 1cm~13cm. CT features of arterial phase into the abscess wall strengthening degree higher than that of normal liver parenchyma and inflammatory reaction with no enhancement; portal venous phase abscess wall enhancement degree decreased, the density slightly higher than normal liver parenchyma and inflammatory reaction with enhanced were density changes; delay abscess wall is enhanced and the density is slightly higher than that of normal liver parenchyma, inflammatory reaction with a low density, the liquefactive necrosis of pus cavity center showed no obvious enhancement in all the 3 phases scanning. MRI plain scan lesions mainly showed T1 is homogeneous or inhomogeneous low signal, T2 is very high signal, the abscess wall was ring or honeycomb enhancement, distribution of abscess interval to strengthen, liquefied area without obvious enhancement. Conclusion Combined with the application of spiral CT dynamic enhancement scan and MRI scan and in the pathology of liver abscess stage clinical diagnosis achieve complementary advantages, can improve the diagnostic accuracy rate, reduce the misdiagnosis rate. It is worthy of clinical diagnosis in the further promotion and application.