Objective To study the ultrasonic and CT features of chromophobe renal cell carcinoma (CRCC). Methods Twenty cases of postoperative pathologically confirmed CRCCs were retrospectively analyzed. All the patients underwent conventional ultrasonography (US), plain and contrast enhanced CT (CECT) scanning, and 15 of them received contrast enhanced US (CEUS). Results In US, CRCCs usually showed hypoechoic (15/20, 75%) and homogeneous echo (16/20, 80%). In CEUS, 9 cases showed homogeneous enhancement and 6 appeared heterogeneous enhancement. And 10 cases showed isochronous enhancement and 5 demonstrated delayed enhancement in the cortical phase of CEUS. And 11 cases manifested low enhancement and 4 showed equal enhancement compared with the renal cortex at the peak time. On plain CT scan, CRCCs showed iso- (n=16), hypo- (n=2) and hyperattenuations (n=2) respectively. CRCCs showed homogeneous (16/20, 80%) and heterogeneous density (4/20, 20%) on plain CT scan. Seven cases (7/20, 35%) contained punctate or patchy calcifications in the center of tumor. On CECT scan, all CRCCs showed mildly to moderately homogeneous enhancement. The enhancement of 11 and 9 CRCCs peaked in the cortical and parenchymal phases respectively. In addition, 3 cases demonstrated stellate scar in the central area. Conclusion Correct preoperative diagnosis of CRCC could be made based on ultrasonic and CT findings, especially tumor homogeneity and mildly to moderately homogeneous enhancement on CECT and CEUS.