Objective To study the skull to repair the blood perfusion of preoperative afterbrain organization change. Methods Selecting 30 cases in our hospital patients with bone repair as the research object, in 2 d, 10 d after operation, preoperative respectively for patients with CT cerebral perfusion imaging, observation and analysis of this group of patients before and after surgery related index of tissue perfusion changes. Results The patients with lateral CBV, CBF value of preoperative cerebral cortex were significantly lower than the healthy side, determined by MTT, TTP values were significantly higher than that of the healthy side, P<0.05. After surgery, CBV, CBF value of lateral cerebral cortex are obviously improved, compared with preoperative determined by MTT, TTP values compared with preoperative significantly decreased (P<0.05). One side of the cerebral cortex after CVB, CB, determined by MTT, TTP values compared with the contralateral has no obvious difference (P>0.05). For this group of patients with preoperative FIM score average (111.64±12.06), the average postoperative FIM is (120.87 ±8.54) points, the comparison, the difference was statistically significant (P<0.04). Conclusions The repair of skull can effectively increase the blood perfusion of lateral cortical area, promote the nerve functional recovery, CT cerebral perfusion imaging is an effective method for monitoring the change of tissue perfusion.