Objective To investigate the effect of fixed partial dentures made by Co-Cr alloy, pure titanium and Ag-Pd alloy on head and neck MRI examination. Methods A total of 39 volunteers with fixed partial dentures in the hospital were selected, and they were examined by head and neck MRI. The 3 common sequences (SE-T1WI sequence, TSE-T2WI sequence and GRE-T2WI sequence) of 3.0T and 1.5T MRI were used to measure and artifacts were analyzed. Results Under different field strength, the artifact area and the maximum artifact diameter of TSE sequence of three restorative materials ranged from high to low was Co-Cr alloy, pure titanium and Ag-Pd alloy, with statistically significant differences between groups (P<0.05). The T1/T2 images of TSE sequence showed loss of signal, changes of signal intensity and image distortion, showing different shapes on different planes. The artifacts of GRE sequence were larger than the TSE sequence, and the overall image quality of its artifacts was poor. Artifacts mainly showed approximate circular signal loss area with unclear boundary. Conclusion The denture restorative material is an important factor affecting the artifact of head and neck MRI. In general, GRE sequence is more sensitive than TSE sequence. MRI with high magnetic field has higher artifact, while Ag-Pd alloy has less influence than Co-Cr alloy or pure titanium.