Objective To analyze the clinical value of 1.5T MRI Dynamic enhancement curve combined with DWI and serum CEA in the diagnosis of breast cancer. Methods In 69 cases of breast cancer from January 2016 to January 2018 in Zhanjiang Second People's Hospital and affiliated hospital of Guangdong medical university as the observation group and 57 cases of benign breast disease patients as the control group; the patients were scanned using a 1.5 T magnetic resonance imaging instrument, analysis curve and DWI image enhancement with dynamic, and detection of serum CEA, the pathological diagnosis as gold the standard analysis of each index value analysis. Results A series of combined diagnostic specificity of 95.24% was significantly higher than that of each index alone and parallel combined diagnosis(P<0.05), the sensitivity of parallel combined diagnosis was 100% significantly higher than that of single and series of diagnostic indexes (P<0.05), and the accuracy rate was 90.48% and the area under the curve series combined diagnosis of 0.951 was significantly higher than that of each index alone and parallel diagnosis (P<0.05). Conclusion 1.5T dynamic contrast-enhanced curve combined with DWI and serum CEA can improve the accuracy of diagnosis for breast cancer, and has high clinical application value.