Objective To study the application value of CT axial scan and coronal scan in the clinical diagnosis and differential diagnosis of nasal sinus neoplasms. Methods 97 patients who underwent CT examination in E.N.T. department of our hospital from August 2013 to August 2015 were selected as the research objects. All patients underwent CT examination, including axial scan and coronal scan. Based on the pathological results, the diagnostic accuracy of different scanning methods was calculated and compared with the results of combined scanning. Meanwhile, the imaging features and key points of differentiation of benign and malignant nasal sinus neoplasms were summarized. Results The pathological results of 97 patients were 56 cases with benign neoplasms and 41 cases with malignant ones. The diagnostic accuracy of CT axial scan was 70.1% (68/97) while of coronal scan was 77.3% (75/97). There were no statistically significant differences between the two. The diagnostic accuracy of axial combined with coronal scan was 88.7% (86/97), which was significantly higher than that of CT axis and coronal scan, respectively. The difference was statistically significant (P＜0.05), which indicated that the axial combined with coronal position was more valuable in diagnosis. Conclusion CT is a non-invasive and higher-resolution examination method which can directly display the size and range of lesions in nasal cavity and sinuses, tumor lesions, communication channels and situation around the lesions. It is helpful for early diagnosis and can provide useful information for making clinical treatment plan. Axial plain scan can be used as a supplement to coronal scan to obtain information such as bone destruction of sinus wall and surrounding tissue invasion and to further improve the diagnostic accuracy.