Objective To investigate the clinical value of multi-slice spiral CT enhanced scanning in the diagnosis of liver space occupying lesions. Methods The imaging data of CT plain scan and enhanced scan of 35 patients (48 lesions) from October 2013 and January 2015 were analyzed retrospectively and were compared with clinical pathology. Results With the clinical pathological examination as the golden standard, the accuracy, sensitivity and specificity of CT plain scan in the diagnosis of liver space occupying lesions were 60.42%, 59.26% and 61.90% respectively, while those of CT enhanced scanning were 93.75%, 92.59% and 95.24%, respectively(P＜0.05). The accuracy of CT enhanced scanning in the diagnosis of liver cancer (92.59%) was higher than that of CT plain scan (59.26%) (P＜0.05). CT plain scan showed small nodule like slightly low density shadow in the liver, without clear edges. The arterial phase scan showed nodular lesions, peripheral enhancement, and some lesions with clear outlines. The portal phase showed that the lesion enhancement decreased. Since there were few cases with liver cyst, liver adenoma or focal nodular hyperplasia, the cases were not analyzed statistically. Conclusion Spiral CT enhanced scanning can improve the detection rate of liver space occupying lesions, which can provide abundant information for clinical treatment.