Objective To OSAHS patients with effective H - UPPP surgery and weight loss at the same time, studing the change of fat in each airway clearance on content were. Methods Selected 20 severe OSAHS patients beween 200901 to 201412 in our hospital , of the effective treatment is HUPPP + 3 months effective weight loss to patients, Before and after effective treatment, patients need PSG, guide and neck MSCT scanning, analysis of nasopharynx fat volume(NPFV)/oropharynx fat volume(OPFV)/ laryngealpharynx fat volume(LPFV)/neck subcutaneous fat volume(NSFV)and tongue body tissue volume(TBSV) changes. Results For OSAHS patients, more effective weight + H - march UPPP surgery before and after treatment, two groups of Statistical data, NPFV and LPFV were not statistically significant difference volume percentage of fat , and no obviously changed before and after the treatment; OPFVand NSFV were statistically significant difference volume percentage of fat, and had obviously changed; There was statistically significant difference before and after treatmentof TBSV, and had obviously changed before and after treatment. Conclusion 1.Before and after treatment, Statistical data of OPFV and NSFV had obviously changed, therefore, consider the fat gap increase lead to throat soft tissue increased, caused airway stenosis, respiratory resistance increased, aggravated OSAHS.2. Statistical data of NPFV and LPFV were rich, That had not obviously changed before and after treatment, so considered its regional fat increased no evidence ,it could increase the risk of OSAHS. 3 Before and after HUPPP + 3 months effective weight loss, Statistical data of TBTV had obviously changed, consided the treatment had significant effect to the tongue body volume. MSCT could do objective evaluation for neck fat volume changes of OSAHS patients with HUPPP + 3 months effective weight loss , and has certain clinical application.