Objective To investigate the application value of multi-slice spiral CT coronary angiography in the follow-up of patients with acute myocardial infarction (AMI) after coronary stent implantation. Methods A total of 58 patients with AMI diagnosed by coronary angiography in our hospital from November 2014 to October 2016 were selected as study subjects. All patients were treated with coronary stent implantation, and follow-up of patients with AMI after coronary stent implantation was evaluated with multislice CT coronary angiography, and the results were compared with those of digital subtraction coronary angiography (CAG). Results In 58 patients, 106 stents were examined with multi-slice spiral CT coronary angiography and CAG. With the results of CAG as control, the sensitivity, specificity, positive predictive value and negative predictive value of multi-slice spiral CT coronary angiography in the diagnosis of instent restenosis were 46.15%, 97.50%, 85.71% and 84.78%, respectively. Conclusion Multislice spiral CT coronary angiography is of great value in evaluating postoperative follow-up of patients, and it can effectively assess the degree of restenosis in patients, which provides important references for clinical rational intervention measures.