Objective To discuss the value of SWI in the differential diagnosis of brain lymphoma and high-grade gliomas. Methods Patients with brain lymphoma and highgrade gliomas were selected as study subjects, and the routine MRI and SWI findings were retrospectively analyzed and semi quantitative scores were performed. Results By the rank test,we could know that the Tumor Magnetic Susceptibility signal(ITSS) grade of brain lymphoma was significantly different from that of high grade gliomas (P<0.05).In SWI,the detection rate of the brain lymphoma and high grade gliomas were not significantly different (P>0.05). There were 17 lesions in the patients with brain lymphoma.The vascular score was 0 and 6, the vascular score was 1 and 9, the vascular score was 2 and 1, and the vascular score was 3.There was a total of 24 lesions High-grade glioma patients,among them,there were 4 lesions with a vascular score of 2,and 20 of the lesions with a vascular score of 3.After a comparative analysis,the difference of vascular score of the patients with brain lymphoma group and high grade glioma group was significantly different (P<0.05). Conclusion SWI can directly display the magnetic susceptibility signal in the tumor,which is helpful for the differential diagnosis of brain lymphoma and high grade gliomas.