Objective To study the changes value of CT perfusion parameters in the evaluation of sensitivity before and after radiotherapy and chemotherapy of cervical cancer. Methods 59 patients with cervical cancer treated with radiotherapy in our hopsital underwent CT plain and enhanced scan. According to the curative effect, the patients were divided into CR group (27 cases), PR group (16 cases), SD group (10 cases) and PD group (6 cases). The differences of CT perfusion parameters of patients with different curative effects in the four groups were compared, including blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface (PS) to evaluate the feasibility of applying changes of CT perfusion parameters in the evaluation of the sensitivity to radiotherapy and chemotherapy of cervical cancer. Results The differences in BF and MTT between the four groups were not statistically significant (F=0.412, F=1.360, P＞0.05) while in BV and PS were statistically significant (F=71.264, F=25.635, P＜0.05). The better the curative effect was, the higher the BV and PS values were. BV values of CR and PR group were significantly higher than those of SD and PD group and CR was higher than PR. The differences between SD and PD group were not statistically significant (P＞0.05); With the deterioration of curative effect, PS decreased. The differences between groups were statistically significant (P＜0.05). Conclusion CT perfusion parameters, blood volume and permeability surface can be used to evaluate the sensitivity of radiotherapy and chemotherapy of cervical cancer and they are of guidance value in the selection of treatment method and judgement of prognosis