Objective To investigate the feasibility of assessing liver fibrosis with volume dynamic contrast enhanced MR imaging of the whole liver. Methods 35 patients with pathologically confirmed the presence of fibrosis, other 89 patients without liver fibrosis patients as the control group. All patients underwent volume dynamic contrast enhanced MR imaging of the whole liver, drawing the time signal intensity curve (TIC) and analyzed its main features, record the time to peak(TTP), maximum slope of increase(MSI) and maximum contrast enhancement ratio(MER). The type of TIC, TTP, MSI, and MER were compared between the case group and control group. Results The types of TIC of AO were no difference between the control group and the case group. The peak time of PV, LHL and RHL of the case group were delayed and had big wave. The type of TIC of LHL and RLH of the case group had platform period．The TTP、MSI、MER of AO, PV, LHL and RHL were significant differences between the S0 to S3 groups(p<0.05), except differences between TTP、MSI of AO(p>0.05). Conclusion The characteristics of TIC from volume dynamic contrast enhanced MR imaging of the whole liver could be used to assessing the liver fibrosis, and had certain diagnostic value.