Objective To explore the effect of ultrasonography and contrast-enhanced computer tomography in the diagnosis of thyroid carcinoma and lymph node metastasis. Methods Retrospective analysis 113 cases of clinical data of patients in our hospital with thyroid cancer from June 2012 to November 2015, all patients underwent ultrasound and enhanced CT, and Performed dissection to lymph trancfer intraoperative by ultrasound (or) enhanced CT prompt during the surgery, and compared the results with postoperative pathological. Results 93 side neck were confirmed metastasis by pathologically of central lymph node metastasis, and 41 side without lymph node metastasis. Sensitivity, accuracy of ultrasound was superior thanCT scan enhanced, the difference was statistically significant (P<0.05), but the difference of specificity, positive predictive value, negative predictive the value of ultrasonography and CT enhanced was not statistically significant (P>0.05). Conclusion For the diagnosis of thyroid cancer, and central lymph node metastasis, ultrasound is batter than enhanced CT, can be choose as a preferred method of examination, but ultrasound and CT can complement each other and accurate diagnosis.