Objective To study the clinical application value of computed tomography (CT) and color doppler ultrasound on the diagnosis of thyroid carcinoma. Methods A retrospective analysis of 98 cases of suspected thyroid cancer patients from September 2015 to January 2014 were collected as the research object, the patients were treated with CT thin layer scanning and color Doppler ultrasound examination, the diagnosis value of combined CT and color Doppler ultrasound and single diagnostic method were evaluated. Results 82 cases of patients were diagnosed as TC. The accurate rate of CT in the diagnosis of papillary thyroid carcinoma was significantly higher than that of color Doppler ultrasound (χ2 =3.521, P<0.05). The sensitivity, specificity, sensitivity, specificity, positive predictive value and negative predictive value of CT on the diagnosis of TC were 89.2%, 27.3%, 70.7% and 56.25%, respectively. The sensitivity, specificity, sensitivity, specificity, positive predictive value and negative predictive value of color Doppler ultrasound on the diagnosis of TC were 88.3%, 21.2%, 54.8% and 62.5%, respectively. The sensitivity, specificity, sensitivity, specificity, positive predictive value and negative predictive value of combined CT and color Doppler ultrasound on the diagnosis of TC were 96.2%, 68.4%, 92.7% and 81.25%, respectively. Conclusion The combined CT and color Doppler ultrasound on the diagnosis of TC was more reliable on the diagnosis of thyroid cancer than that of CT or color Doppler ultrasound, alone. And it has better clinical application value.