Objective To comparatively analyze the clinical diagnostic value of CT coronary angiography and coronarography in the diagnosis of coronary artery disease. Methods 94 cases of patients with suspected coronary heart disease admitted into the hospital from April 2012 to March 2015 were selected as the research object and were examined by CT coronary angiography (CTA) and coronarography (CAG). With CAG as thegold standard, the specificity, sensitivity, accuracy, the rates of misdiagnosis and missed diagnosisof CTA in the effective segment were assesed. Results ①There were 1034segments of blood vessels evaluated in 94 patients. There were a total of 977 segments (94.5%) of vessels in the results of CTA diagnosis consistent with CAG and 57 segments not (5.5%). ② The specificity diagnosed by CTA was 93.9% (155/165), the sensitivity 94.7% (832/879), the accuracy 95.5% (987/1034), the rate of misdiagnosis 4.5% (47/1034) and misdiagnosis1.0% (10/1034). Conclusion CTA is ideally noninvasive with operability and convenience. In clinic, it can be taken as an effective way of early screening of coronary artery disease (CAD). For patients with positive CT angiography (CTA), to treat themwith CAG can shorten the treatment time and save the cost of diagnosis and treatment, improve the effectiveness and accuracy of diagnosis and treatment and ensure that the treatment can be carried out smoothly.