Objective To observe the MSCT features of invasive pulmonary fungal infection, To evaluate the prognostic value of MSCT. Methods 115 cases diagnosed as invasive pulmonary aspergillosis patients from February 2011 to October 2015 were chosen as the research object, all underwent chest MSCT examination, To observe the MSCT findings of invasive pulmonary aspergillosis, Comparison of blood disease and blood disease of non invasive pulmonary aspergillosis MSCT signs, Analysis and cure group and death group of patients with deterioration of the changes of 0W, 2W, 4W and 8W in treatment of pulmonary lesion morphology. Results Invasive pulmonary aspergillosis in 85 cases of infection, 81 cases were diagnosed correctly by MSCT, The MSCT findings included patchy shadow, consolidation, mass, nodules or cavities, and branches of sign, sign and halo sign, The maximum number of empty, Followed by nodules, patchy shadow and halo sign. Lesions in the bilateral multiple, middle and lower lung. With the blood disease of non invasive pulmonary aspergillosis MSCT features, The blood spot disease shadow, mass, nodules or cavities, and sign, sign and halo sign is the proportion of branches were significantly increased, The differences between groups were statistically significant (P<0.05). The treatment of 4W and 8W, the cure group shadow plaques, nodules and lesions void ratio were significantly lower than the deterioration of the death group, The difference was statistically significant (P<0.05). Conclusion MSCT features of invasive pulmonary aspergillosis lesions accurately, Has a high diagnostic accuracy, It can evaluate the prognosis of patients.