Objective To explore the effect evaluation of the CT scan and the enhanced CT scan on the cirrhotic portal hypertension and hypersplenism, providing the basis for the clinical treatment of the PHT and hypersplenism disease. Methods A total of 72 cases with PHT with hypersplenism who were treated in the hospital from Jan 2015 to Dec. 2015 were recruited as the study objects, The patients of PHT with hypersplenism were examined by the CT scan (the scan group) firstly and the enhanced CT scan group (the enhanced group) then. The indicators were compared between the two groups, mainly on the positive rate of examination, the clinical effect of diagnosis, and the internal structural lesions of viscera,statisticing the experimental data, analing the radiographic image, and recording the detailed information. Results The positive detection rate of serious PHT with hypersplenism in the enhanced group was significantly higher than that in the scan group, and the difference was statistically significant(P＜0.05). The diagnosis effect (sensitivity, Specific degrees, positive predictive rate, index) in the enhanced group was significantly better than that in the scan group, and the difference was statistically significant(P＜0.05). The radiographic images in the enhanced group was significantly more clear and accurate than that in the scan group, providing a good basis for clinical diagnosis and treatment. Conclusion The enhanced CT scan could be effective for the diagnosis and treatment in the patients with PHT with hypersplenism,which had the clinical effect of high resolution and good specificity, quickly and easily, reasonably and effectively , having the high clinical value.