Objective Imaging Features of Liposarcoma on Dynamic Contrast-enhanced Spiral CT were analysed retrospectively to raise the level of imaging diagnosis. Methods 28 cases of liposarcoma confirmed by pathology from July, 2008 to February, 2014 at the first and fourth affiliated hospital of Guangxi medical university were analyzed retrospectivly. The imaging features of liposarcoma on dynamic contrast-enhanced spiral CT were studied together with the clinical data and pathological results. Results 28 cases of liposarcoma, the total detection rate of fat component in the tumors on CT is 71% (20/28, 71%), the detection rate in the sclerosing liposarcoma and myxoid liposarcoma are lower than the another subtypes (respectively as follows: 0/2, 0%, 5/10, 50%). The CT value of "mucus component" is 0-20HU, and the "mucus component" was seen in all myxoid liposarcoma (10/10, 100%). Dynamic contrast-enhanced CT: both the measuring areas within the tumors and the surrounding normal tissues were seen delayed enhancement trend (totality P＜0.05, and each phase pairwise comparisons both P＜0.05), but the degree of the enhancement within the tumors was more obvious; a separate analysis of myxoid liposarcoma, the measuring areas within the tumors were seen delayed enhancement trend (totality P＜0.05), but there was no statistical difference between the routine scan and the arterial phase(P＞0.05), there were statistical differences between the routine scan and venous phase, arterial phase and venous phase (both P＜0.05). Conclusion The fat component of some subtypes of liposarcoma is rare on CT, some myxoid liposarcomas appear to be cystic at nonenhanced CT imaging, dynamic enhanced CT can help diagnosis.