Objective To explore clinical value of magnetic resonance diffusion weighted imaging (DWI) combined with magnetic sensitive weighted imaging (SWI) in the diagnosis of cerebral infarction and acute phase of cerebral hemorrhage. Methods Sixty patients with acute cerebral infarction (Group A) and 24 patients with acute cerebral hemorrhage (Group B) admitted by the Hospital from may, 2014 to may, 2015 were selected as research subjects, all patients underwent 1.5T magnetic resonance DWI and SWI sequence examinations, test results of patients in two groups were observed, and they were compared to those of 12 normal volunteers (control group). Results DWI signal of patients at acute stage in Group A was higher, and the signal intensified with the passage of time, borders of lesions converted from fuzziness to clearness, the positive rate was 100.0%, and SWI showed equisignal signs. Acute DWI hematoma center showed low signal in Group B, periphery took high signal, and the signal intensified with the passage of time, while SWI was uniform low signal. ADC value in Group A significantly decreased when compared to that of patients in the control group, but the decrease extent was not significant when compared to that of patients in the control group, and gradually decreased as the elapse of time, ADC value of patients in Group B significantly decreased, but no obvious change occurred with the passage of time, and the decrease degree of ADC value in Group B was significantly greater than that of patients in Group A(P ＜0.05). PV value of patients in Group A was normal, but local PV value decreased when hemorrhagic transformation occurred, and the decrease degree of PV value of patients in Group B significantly was greater than that of patients in Group A(P＜0.05). Conclusion Imaging appearances of DWI and SWI examinations during cerebral infarction and acute phase of cerebral hemorrhage are different, and DWI combined SWI applied in acute cerebrovascular disease inspection can improve the diagnostic accuracy, contributes to timely detect hemorrhagic transformation after cerebral infarction, and delivers important value for clinical treatment.