Objective To assess the value of MSCT and post-processing techniques in diagnosis of the intra-lobar pulmonary sequestration. Methods MSCT findings were analyzed retrospectively in thirteen patients with surgical and pathology conformed intra-lobar pulmonary sequestration, all patients underwent CT plain scan and contrast enhanced ,the vessels related to the lesions were recon by post-processing techniques ,then compared with the surgical results. Results four cases were located at the posterior basal segment in the right lower lobe. and the the rest of nine cases lesions were found in the basal segment of the left lower lobe, include seven cases were located at the posterior basal segment of the left lower lobe; One case was showed as single loculated cyst contains of air. and eight cases present as multi-loculated cyst contains of air with／ fluid or in without contrast enhancement of cyst wall, four cases presented as round like mass with moderate enhancement. Angiography post-processing technique displayed abnormal supplying vessels in all patients(ten cases from descending aorta and three cases from abdominal aorta)and displayed the courser、origin、and branches of lesions clearly，which was consistent with surgery. Conclusion MSCT angiography with postprocessing reconstruction techniques can depict supplying artery clearly of intra-lobar pulmonary sequestration and shows great value in the diagnosis of intra-lobar pulmonary sequestration，the conventional angiography technique might be replaced．