Objective To explore the second-generation dual-source CT low-dose whole liver perfusion method in the blood supply of primary liver cancer hepatic arterial chemoembolization (TACE) before and after. Methods Primary liver cancer and the use of TACE treatment of patients with a total of 32 people, including 27 males, 5 females, aged 31 to 76 years. Two groups of patients were using the kV, mAs values of different scans. Preoperative 7 days and 20 days respectively after three regular scans and perfusion scan. The A, B perfusion scan radiation doses were associated with liver conventional three scanning, water phantom scan radiation dose were analyzed. Results The two groups of patients before and after embolization of low-dose dual-source CT perfusion scan to good effect, to obtain an accurate scan data and a clear volumetric image. Two conventional liver enhanced scan and dual source CT perfusion scan using a single low-dose sample t-test, A: P <0.05; B: P> 0.05. Group A Group B radiation agents representing low, relative to conventional plain and liver scan radiation dose required to enhance closer. Conclusion The second-generation dual-source CT significantly reduce the value kV, mAs value scanning, you can capture a clearer picture of liver low-dose infusion, and the second-generation dual-source CT low-dose whole liver perfusion method in primary liver cancer the TACE technique to observe the effect of the blood supply before and after treatment is good, worthy of widespread use.