Objective Comparison and analysis of CT perfusion and the diagnostic value of molybdenum target photography drug mammary gland disease. Methods Selection in our hospital during August 2013-July, 2014, 78 cases of patients with suspected breast lesions with CT perfusion examination and X-ray photography first, at the same time, compared with the results of clinical pathology. Results The study found that molybdenum target X-ray photography in the diagnosis of right for 61 cases, the accuracy is 78.21%; CT perfusion in the diagnosis of right for 70 cases, the accuracy is 89.74%; Compare the two diagnostic accuracy (X2 =5.05, P<0.05). Perfusion CT diagnostic accuracy was 90.00% (18/20) compared with line of molybdenum target X 25.00% (5/20) (X2 =18.64, P<0.05). Perfusion CT diagnostic accuracy was 81.82% (45/55) compared with line of molybdenum target X 20.00% (11/55) (X2 =20.38, P<0.05). Perfusion CT diagnostic accuracy was 82.61% (19/23) compared with line of molybdenum target X 73.91% (17/23) (X2 =4.54, P>4.54). Perfusion CT diagnostic accuracy was 27.91% (12/43) compared with line of molybdenum target X 93.02% (40/43) (X2 =8.56, P<0.05). Conclusion Both in the diagnosis of breast disease all have certain advantages, therefore, the clinical diagnosis of breast disease patients can choose according to actual situation or used in combination, to improve accuracy of clinical diagnosis, early treatment, improve the quality of survival.