Objective To observe the effect of integrated mental and physical nursing intervention on role transition and breastfeeding in full-term delivery women. Methods 86 cases of full-term delivery women were randomly divided into control group (43 cases) and observation group (43 cases). The control group was given routine nursing, and the observation group was given integrated mental and physical nursing. The milk yield in 4d and breastfeeding rate 42d after delivery in the two groups were observed and compared, and at the same time the scores of self rating anxiety scale (SAS) and self rating depression scale (SDS) before and after nursing were compared. Results There was no significant difference in milk yield between the two groups 1d and 2d after delivery (P>0.05). 3d and 4d after delivery, the milk yield in the observation group was obviously higher than that in the control group, and their difference was statistically significant(P<0.05), the exclusive breastfeeding rate in the observation group was 74.42% which was obviously higher than that in the control group 55.81%, and the difference was statistically significant (P<0.05), after nursing, the SAS and SDS scores in the observation group were significantly lower than those in the control group, and their differences were statistically significant (P<0.05). Conclusion Integrated physical and mental nursing intervention can not only promote the role transition of full-term delivery women to mothers, but also improve the milk yield amount and breast-feeding rate. Thus it is worthy of clinical promotion.