Objective To observe the clinical effect of cerebroside glycoside and Carnosine in patients with ischemic cerebrovascular disease and its effect on neurological function. Methods 80 patients with ischemic cerebrovascular disease treated in our hospital from August 2015 to February 2017 were selected. according to the treatment, the patients were divided into study group (n=40 cases) and control group (n=40 cases), the control group was treated by Xuesaitong injection, the study group was treated by Xuesaitong injection combined with cattle cerebroside glycoside and carnosine treatment, the clinical effect and NIHSS score were compared. Results There was no significant difference between the study group and the control group before treatment (P>0.05). The NIHSS score in group 2 after treatment was lower than that in the control group, and the study group (92.5%) was better than the control group (75%). the difference between the two groups was significant (P<0.05 ). The incidence of adverse reaction was 10.0 % in the study group and 5.0 % in the control group, the difference was not significant (P>0.05). Conclusion The patients with ischemic cerebrovascular disease receive cerebroside glycoside and Carnosine, which can effectively improve the neurological function of patients, and it is worth to be used in clinical practice.