Objective To study the effect of ipratropium bromide combined with budesonide inhalation on bronchospasm and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 92 patients with acute exacerbation of COPD in our hospital were taken as the clinical objects, and they were divided into observation group (46 cases) and control group (46 cases) according to their orders of treatment. Both groups were given routine treatment and ipratropium bromide, besides the observation group was given additional budesonide inhalation. The changes of bronchospasm and lung function related indicators in the two groups before and after treatment were observed and compared. Results There was no difference between the two groups before treatment in the indexes of airway and lung function(P>0.05). After treatment, the indexes of airway and lung function were improved, and the improvement of the observation group was better than that of the control group, and the total effective rate in the observation group was higher than that in the control group, and their differences were statistically significant(P<0.05). Conclusion The improvement effect of ipratropium bromide combined with budesonide inhalation on bronchospasm and lung function in patients with acute exacerbation of COPD was more significant than that of ipratropium bromide alone.