Objective To investigate the curative effect and safety of Huachansu capsule combined with concurrent chemoradiotherapy in treatment of local advance esophageal carcinoma. Methods 84 cases of local advance esophageal carcinoma in our hospital from January 2015 to December 2016 were selected and divided into observation group and control group, 42 cases in each group. Patients were all given concurrent chemoradiotherapy, and observation group plus Huachansu capsule treatment. Clinic effect, toxicity occurrence condition of chemoradiotherapy of the two groups were compared. Difference of immunological function (T-lymphocyte subsets) of the two groups before and after treatment was evaluated. Results ①Total efficiency of observation group was higher than control group (P<0.05), toxic and side effect rate of chemoradiotherapy was lower than control group (P<0.05). ②6w after treatment, CD3+ , CD4+ , CD4+ /CD8+ level of the two groups were all increased (P<0.05), growing rate of observation group was larger than control group (P<0.05), the difference of CD8+ level before and after treatment had no statistic significance (P>0.05). Conclusion Huachansu capsule combined with concurrent chemoradiotherapy can lower toxicity reaction of chemoradiotherapy, improve immunological function, and promote curative effect of local advance esophageal carcinoma.