Head and Neck Imaging
Correlation between Morphological Features of MRI and Specific Receptor Expression in Invasive Ductal Carcinoma
Author：LIU Shu-yi, LIU Yan
affiliation：MR Room, Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang 830011, China
PDFAbstract
Objective To investigate the MRI feature of invasive ductal carcinoma (IDC) in correlation with the expressions of ER, PR and HER-2. Methods A total of 97 patients with histologically confirmed IDC were enrolled in this study. Conventional MRI was performed on all patients before surgery. The relationships among MRI features(spicule sign and lobulation sign) and expressions of ER, PR and HER-2 were analyzed. Statistical analysis was performed using chi-square test with statistical significance defined as P＜0.05. Results The tumors with speculated margins had higher expression levels of ER, PR and HER-2 than tumor with spiculation(P＜0.05). There were also relative lower expression levels of PR in tumors with lobulation than tumors without lobulation(P＜0.05) whereas tumor with lobulated margins had higher expression levels of ER and HER-2 than tumor without lobulation(P＜0.05). Conclusion The expression of ER, PE and HER-2 is related to the burr sign of infiltrating ductal carcinoma, and the expression of HER-2 is related to lobulated sign. It has important clinical significance for the comprehensive evaluation of the degree of malignancy of breast cancer．
【Keyword】Breast Cancer; Hormone; Immunohistochemistry; Magnetic Resonance Imaging
【Chart number】R737.9；R445.2
【Document Identification Number】A
【DOI】10.3969/j.issn.1672-5131.2018.12.014
Chinese journal of CT and MRI
th16Volume， th 12 Issue
2018Year12Month
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