Objective To investigate the characteristics of CT perfusion imaging and the relationship with pathological parameters in patients with non-small cell lung cancer (NSCLC). Methods The lung CT perfusion imaging data of 48 patients with NSCLC confirmed by operation and pathology during the period from May 2015 to May 2016 were analyzed retrospectively. The relationships between pathological parameters and CT perfusion parameters such as blood flow (BF), blood volume (BV), peak enhancement image(PEI) and mean transit time (MTT) were analyzed. Results There were no significant differences in characteristics of CT perfusion imaging between different histological types of NSCLC (P>0.05). The BF and PEI values of patients with lymph node metastasis were significantly lower than those in patients without lymph node metastasis. With the increase of differentiation degree, BF and PEI values increased gradually. The BF value of patients with low pTNM stage was significantly higher than that of patients with high stage. The BF value of patients with metastasis or recurrence was significantly lower than that of patients without(all P<0.05). Conclusion CT perfusion imaging can reflect the degree of malignancy of tumors to some extent by evaluating the status of angiogenesis, which provides important guidance for clinical treatment and prognosis evaluation of patients with NSCLC.