Objective To evaluate the application value of contrast-enhanced ultrasound combined with CT in the diagnosis of focal nodular hyperplasia (FNH). Methods A total of 100 cases of patients with FNH who were enrolled in the hospital from January 2016 to January 2018 were selected for the study. All patients were given CT and contrast-enhanced ultrasound. The findings features of CT and contrast-enhanced ultrasound were analyzed. CT and contrast-enhanced ultrasonography were analyzed to compare the accuracy of CT, contrast-enhanced ultrasonography and CT combined with contrast-enhanced ultrasonography in detecting FNH. Results The CT findings of FNH showed that the lesions were evenly enhanced in arterial phase, and the findings of contrast-enhanced ultrasound showed lesions were with rapid and uniform and high enhancement in arterial phase. A total of 80 lesions were detected by CT, and the plain scan showed that 44 lesions were low-density and significantly enhanced in arterial phase, in venous phase and delayed phase, 24 and 26 lesions decreased to iso-density, respectively. 85 lesions were detected by contrast-enhanced ultrasound, and 83 lesions were hyperechoic in arterial phase, and 16 lesions in venous phase and 50 lesions in delayed phase were reduced to equal echo. The detection rate of FNH patients by CT combined with contrast-enhanced ultrasound was significantly higher than that by single detection(P<0.05). Conclusion Contrast-enhanced ultrasound combined with CT has a high detection rate in the diagnosis of FNH.