Objective To explore the application value of volume rendering of multislice spiral CT in the diagnosis of limb fractures. Methods A total of 59 patients with limb fractures admitted and treated in our hospital from April 2017 to December 2017 were selected. To compare the imaging quality of CT non-enhanced scan and CT volume rendering for different parts of fractures, and to analyze the application value of volume rendering of multi-slice spiral CT in diagnosing limb fractures. Results The clinical data of 59 patients showed that there were 19 cases of elbow fracture, 12 cases of wrist fracture, 9 cases of knee fracture, 8 cases of ankle fracture and 11 cases of femoral fracture. In comparison of image quality scores of different fracture sites, VR showed significantly higher image quality scores of elbow fracture, wrist fracture, knee fracture, ankle fracture and femur fracture than that of CT non-enhanced scan, and the differences were statistically significant (t value was 3.807, 4.143, 4.346, 2.971, 4.660, P<0.05). The excellent and good rate of VR image quality was 100%, and the excellent and good rate of CT non-enhanced scan image quality was 98.30%. The difference between the two data had no statistical significance (χ2 =1.009 P=0.315). Conclusion The volume rendering of multi-slice spiral CT can clearly and comprehensively show the specific conditions of limb fractures, and the imaging quality is high, which is more conducive to the accurate diagnosis of image and worthy of clinical promotion.