Objective To explore the effect of comfort care model in patients with brachial artery coronary intervention. Methods A total of 50 cases of 2014-2016 patients by brachial artery coronary intervention, divided into control group and experimental group with 25 cases in each group, the control group received routine preoperative nursing, postoperative sheath tube, puncture and compression hemostasis, bandage ring compression bandage puncture point, elbow braking for 8 hours, 8 hours after the demolition bandage. The experimental group except the control group before surgery, preoperative nursing, nurse patients with repeated practice can not bend and straighten elbows keep the upper conditions how to transform a variety of positions and how to place the optimal position of the upper limb after the operation, the same method of pressurized bandaging the puncture point after the puncture on the side limb from the elbow brace in braking center placement according to the patient's arm, adjust the tightness of the brace, 8 hours after the removal of brace and bandage. Results The comfort of the two groups was statistically significant (P<0.05). Conclusion The application of comfort care model in patients with brachial artery coronary intervention improves the comfort of patients, enhances the compliance of patients, and reduces the incidence of postoperative complications.