Objective To summary the clinical experiences of blood purification treatment for bee stings. Methods 11 patients with bee stings were collected in the department of nephrology of People’s hospital of Qixingguan District, the diagnosis and treatment of bee stings time, clinical manifestations, treatment methods and treatment results were analyzed and summarized. Results 11 patients 10 cases of hemodialysis combined with hemoperfusion, hospital stay 1-11 days, an average of 5.3 days; all patients meet with the clinical cure. Conclusion Bee venom can cause severe human allergic reactions, severe bee stings allows patients with multiple organ dysfunction, serious life-threatening. Hemodialysis joint hemoperfusion blood purification treatment is the bases not only help clear the venom, but also help maintain water and electrolyte and acid-base balance of the patient. Blood purification therapy should be concentrated as early as possible, thus improving the prognosis of patients.