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布地奈德联合不同药物雾化吸入治疗儿童哮喘临床分析

作者:傅光华1 谭 清1 李 黎2 余韶卫3 梁美嫦1

所属单位:1.广东省云浮市罗定市妇幼保健院儿科 (广东 云浮 527200)2.广东省云浮市罗定市人民医院儿科 (广东 云浮 527200)3.暨南大学医学院第四附属医院(广州市红十字会医院)儿科 (广东 广州 510613)

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摘要

目的 观察评价布地奈德联合特布他林及异丙托溴铵雾化吸入治疗哮喘的临床果。方法 选择2017年2月-2018年3月 期间我院收治的哮喘患儿86例,按照数字表法随机分为两组,对照组43例给予布地奈德联合特布他林雾化吸入治 疗;观察组43例在对照组基础上给予异丙托溴铵雾化吸入治疗,并比较两组治疗后的临床效果。结果 观察组总有 效率为95.35%显著地高于对照组的63.79%(χ2 =13.7712,P=0.0000),观察组气喘、咳嗽和哮鸣音消失时间及住院 时间均显著地短于对照组(分别t=2.1735、3.0986、2.7142、2.2106,P<0.05),两组患儿FVC、FEV1、FEV1/FVC均 明显的升高,且治疗后观察组均明显的高于对照组(分别t=1.9758、2.1642、8.4136,P<0.05)。结论 布地奈德联 合特布他林及异丙托溴铵雾化吸入治疗儿童哮喘疗效确切,能够有效的降低机体炎症反应并改善肺功能,显著地缩 短临床症状消失时间,值得临床推广应用。

Objective To observe the clinical results of budesonide combined with terbutaline and ipratropium bromide inhalation for asthma. Methods A total of 86 children with asthma admitted to our hospital from February 2017 to March 2018 were randomly divided into two groups according to the digital table method. 43 patients in the control group were given budesonide combined with terbutaline inhalation. Forty-three patients in the observation group were given ipratropium bromide atomized inhalation on the basis of the control group, and the clinical effects after treatment were compared between the two groups. Results The total effective rate of the observation group was 95.35%, which was significantly higher than that of the control group(63.79% (χ2 =13.7712, P=0.0000). The disappearance time and hospitalization time of asthma, cough and wheezing in the observation group were significantly shorter than that of the control group. (T=2.1735, 3.0986, 2.7142, 2.2106, P<0.05, respectively), FVC, FEV1, FEV1/FVC were significantly increased in both groups, and the observation group was significantly higher than the control group after treatment (t=1.9758, 2.1642, 8.4136, P<0.05). Conclusion Budesonide combined with terbutaline and ipratropium bromide inhalation in children with asthma is effective, can effectively reduce the body's inflammatory response and improve lung function, significantly shorten the disappearance of clinical symptoms, it is worthy of clinical application.

【关键词】儿童哮喘;布地奈德;特布他林;异丙托溴铵;雾化吸入

【中图分类号】R256.12

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2019.03.022

前言

随着近年来社会经济逐渐地发展,城市化和工业 化日益显著,空气污染具有显著地加重,全球发生率 呈逐年增长趋势,支气管哮喘是以慢性气道炎症和气 道高反应为特征的疾病。我国儿童哮喘发病率居高不 下,哮喘是儿童最常见的呼吸系统疾病中的一种异质 性疾病,主要是受遗传、环境等因素共同作用的多基 因疾病,其临床表现为病程较长反复喘息、气促、胸 闷及咳嗽,严重危害儿童身心健康[1-3]。哮喘的发病基础是慢性气道炎症,治疗主要为防治急性发作和控 制哮喘相关症状及提高生活质量[4-5]。吸入糖皮质激 素联合长效β2受体激动剂雾化吸入及白三烯受体拮 抗剂为主要控制药物治疗儿童哮喘具有协同作用,能 够显著地控制患者病情[6]。本研究观察评价分析了布 地奈德联合特布他林及异丙托溴铵雾化吸入治疗儿童 哮喘患儿43例,取得了较为理想的效果,现总结分析 报道如下。