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结核灵联合西医常规治疗颈部淋巴结结核的疗效观察

作者:张 亮 梅月志 李 坤 戴宇彪

所属单位:广东省东莞市第六人民医院 (广东 东莞 523008)

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摘要

目的 观察评价结核灵联合西医常规治疗颈部淋巴结结核(CTL)的临床效果。方法 将86例颈部淋巴结核患者,随 机对照试验(RCT)分为两组,对照组43例给予西医常规治疗;观察组43例在对照组治疗基础上加用结核灵片,并 比较两组的临床效果。结果 观察组总有效率为95.35%明显高于对照组79.07%(χ2 =5.1079,P=0.0000),观察组总 不良反应发生率为11.63%显著地低于对照组34.88%(χ2 =6.5152,P=0.0000),而1a后复发率为0显著地低于对照组 20.93%(χ2 =5.0260,P=0.0000)。结论 结核灵联合西医常规治疗颈部淋巴结结核(CTL)安全可靠,疗效显著,能够 有效的降低不良反应发生率,复发率低。

Objective To observe and evaluate the clinical effect of tuberculosis combined with Western medicine in the treatment of cervical lymph node tuberculosis (CTL). Methods Eighty-six patients with cervical lymphatic tuberculosis were randomly divided into two groups. The control group was treated with traditional Chinese medicine in 43 cases. The observation group was treated with tuberculosis tablets in the control group. Clinical effect. Results The total effective rate of the observation group was 95.35%, which was significantly higher than that of the control group (79.07% (χ2 =5.1079, P=0.0000). The total adverse reaction rate of the observation group was 11.63%, which was significantly lower than that of the control group (34.88%) (χ2 =6.5152). P=0.0000), and the recurrence rate after 1a was significantly lower than that of the control group by 20.93% (χ2 =5.0260, P=0.0000). Conclusion Tuberculosis combined with Western medicine for the treatment of cervical lymph node tuberculosis (CTL) is safe and reliable, with remarkable curative effect, which can effectively reduce the incidence of adverse reactions and low recurrence rate.

【关键词】颈部淋巴结核;结核灵;中西医结合疗法

【中图分类号】R522;R551.2

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2019.03.017

前言

颈部淋巴结结核 ( c e r v i c a l t u b e r c u l o u s lymphadenopathy,CTL)又被称为瘰疬,是由于人体 受到结核分枝杆菌的感染引起淋巴系统结核病,占所 有淋巴结结核的80%~90%,根据临床表现、病程及病 情的发展分为结节型、浸润型、脓肿型和溃疡窦道 型,由于早期症状表现不典型,而且影像学检查的特 异性低,发现本病时多数病程已有半年,是发病率较 高的肺外结核疾病[1-3]。CTL多见于儿童和青少年,具 有不痒、不痛及生长缓慢的特点,若不及时给予治 疗,则将会导致病人的颈部皮肤溃烂,并形成窦道, 经久不愈,不仅给病人造成严重的身心创伤,还会降 低生存质量(QOL),大多数病人经过正规抗结核治疗 都能治愈。但仍有10.1%~31.6%病人的病情还可以会 发展到寒性脓肿,且常规用药疗程长、效果差[4-5]。