目的 分析血清半胱氨酸(Hcy)、血管内皮生长因子(VEGF)、血清转化生长因子-β1(TGF-β1)水平与早期糖尿病肾 病(DN)的关系。方法 选取我院2015年1月-2017年1月年间收治的120例2型糖尿病(T2DM)患者作为研究对象，根据 其尿清蛋白排泄率(UAER)水平将其分为单纯T2DM组(n=61例)与早期DN组(n=59例)，同时选取120例同期行健康体检 者作为对照组，比较三组血清Hcy、VEGF、TGF-β1水平，分析其与早期DN的关系。结果 Hcy、VEGF、TGF-β1水平 在对照组、单纯T2DM组、早期DN组中均逐渐增高，组间差异显著(P<0.05)；经Logistic分析得出血清Hcy、VEGF、 TGF-β1均是早期DN的危险因素。结论 血清Hcy、VEGF、TGF-β1水平是早期糖尿病肾病有效的生化标志物，可用于 临床检测。

Objective To analyze the relationship between levels of serum homocysteine (Hcy), vascular endothelial growth factor (VEGF) and serum transforming growth factor-β1 (TGF-β1) and early diabetic nephropathy (DN). Methods 120 patients with type 2 diabetes mellitus (T2DM) admitted to our hospital from January 2015 to January 2017 were selected for the study. According to the urinary albumin excretion rate (UAER) level, they were divided into simple T2DM group (n=61) and early DN group (n=59), and another 120 healthy examiners at the same time period were selected as control group. The levels of serum Hcy, VEGF and TGF-β1 were compared among the three groups, and their relationship with early DN was analyzed. Results The levels of Hcy, VEGF and TGF-β1 were gradually increased in control group, T2DM group and early DN group, and the differences between-groups were significant (P<0.05). Logistic analysis showed that serum Hcy, VEGF and TGF-β1 were all risk factors for early DN. Conclusion Serum levels of Hcy, VEGF and TGF-β1 are effective biochemical markers for early diabetic nephropathy, and they can be used for clinical detection.