摘要
目的 观察右美托咪定联合舒芬太尼对三叉神经痛(TN)患者术后镇痛效果。方法 选取我院2015年1月-2017年1月收 治的60例择期行TN手术患者为对象,采用随机数字法将其分为对照组和实验组各30例,对照组术后给予舒芬太尼 进行镇痛,实验组在对照组的基础上给予右美托咪定进行镇痛。比较两组镇痛效果及不良发应。结果 实验组术 后6h、12h、24h及48h的VAS评分均显著于对照组(P<0.05);实验组总并发症发生率为5.00%显著低于对照组的 18.33%(P<0.05)。结论 右美托咪定联合舒芬太尼对TN患者术后镇痛疗效显著,且安全性较高,值得进一步推广 使用。
Objective To observe the effect of dexmedetomidine combined with sufentanil on postoperative analgesia in patients with trigeminal neuralgia (TN). Methods 60 patients undergoing elective TN surgery in the hospital from January 2015 to January 2017 were enrolled. They were divided into control group and experiment group by random number table method, 30 cases in each group. The control group was given sufentanil for analgesia after surgery. On this basis, the experiment group was additionally given dexmedetomidine for analgesia. The analgesic effect and adverse reactions were compared between the two groups. Results The VAS scores of the experiment group at 6h, 12h, 24h and 48h after surgery were significantly higher than those of the control group (P<0.05). The total incidence of complication in the experiment group was significantly lower than that in the control group (5.00% vs 18.33%) (P<0.05). Conclusion The curative effect of dexmedetomidine combined with sufentanil is significant on postoperative analgesia in TN patients, with relatively higher safety. Which is worthy of further promotion.
【关键词】右美托咪定;舒芬太尼;三叉神经痛;术后;镇痛
【中图分类号】R971+.1
【文献标识码】A
【DOI】10.3969/j.issn.1009-3257.2019.02.002
前言
三叉神经痛(TN)系指发生在一个或多个三叉神经 支配区域内阵发性剧烈疼痛[1]。其发病机制至今尚无 明确定论,三叉神经微血管压迫所致神经脱髓鞘学 说以及癫痫样神经痛学说是目前TN最为常见病因学 说[2]。临床上常采用手术方式进行治疗,但长期的疼 痛容易造成患者焦虑和恐惧等心理,加之手术的刺 激,患者术后更容易发生躁动、睡眠障碍等并发症, 从会影响患者的恢复,这给患者造成严重的困扰,因 此对TN患者术后进行镇痛成为目前研究的要点[3]。研 究表明[4],右美托咪定可减少阿片类药物用量,增加 其镇痛效果,与舒芬太尼联合具有协同作用。笔者为 进一步研究右美托咪定联合舒芬太尼对TN患者术后镇 痛效果,本研究将右美托咪定联合舒芬太尼应用于TN 术后患者中,探讨其应用效果,现具体报道如下。
罕少疾病杂志
第26卷, 第 2 期
2019年03月
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