目的 分析比较瑞舒伐他汀和阿托伐他汀对早发急性心肌梗死(AMI)血清心肌损伤标志物水平的影响。方法 选取我 院104例早发AMI患者为研究对象，采用随机数字表法分为瑞舒伐他汀组(观察组，n=52)和阿托伐他汀组(对照组， n=52)。比较两组治疗前及治疗6个月后血脂水平[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、 炎症反应[超敏Ｃ-反应蛋白(hs-CRP)、乳脂肪球表皮生长因子8(MFG-E8)]、心肌损伤标志物水平[肌酸激酶同工酶 (CK-MB)、超敏肌钙蛋白T(hs-TnT)]差异。结果 治疗6个月后，两组血清LDL-C、hs-CRP及血浆CK-MB、hs-TnT水平 均较治疗前降低(P＜0.05)，血清HDL-C、MFG-E8水平则较治疗前升高(P＜0.05)，且观察组变化幅度均大于对照组 (P＜0.05)。结论 瑞舒伐他汀及阿托伐他汀用于治疗早发AMI效果均较好，但瑞舒伐他汀对患者血脂调节、炎症抑 制、心肌损伤改善等作用优于阿托伐他汀，于患者病情转归更有利。

Objective To compare the effects of rosuvastatin and atorvastatin on serum myocardial injury markers levels in earlyonset acute myocardial infarction (AMI). Methods A total of 104 patients with early-onset AMI in our hospital were selected for the study and were divided into rosuvastatin group (observation group, n=52) and atorvastatin group (control group, n=52) according to the random number table method. The blood lipids levels [low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)], inflammatory response [hypersensitive C-reactive protein (hs-CRP), milk fat globule epidermal growth factor 8 (MFG-E8)] and myocardial injury markers levels [creatine kinase isoenzyme (CK-MB), hypersensitive troponin T (hs-TnT)] were compared between the two groups before treatment and after 6 months of treatment. Results After 6 months of treatment, levels of serum LDL-C, hs-CRP, and plasma CK-MB and hs-TnT in the two groups were decreased compared with those before treatment (P<0.05) while levels of serum HDL-C and MFG-E8 were increased compared with those before treatment (P<0.05), and the changes in observation group were greater than those in control group (P<0.05). Conclusion Rosuvastatin and atorvastatin both have good effects in the treatment of early-onset AMI, but rosuvastatin is superior to atorvastatin in improving blood lipids regulation, inflammation inhibition and myocardial injury, and it is more favorable for disease outcomes.