目的 探讨硫辛酸联合甲钴胺治疗急性脑梗死的疗效及对患者美国国立卫生研究院卒中量表(NHISS)评分、氧化应激 水平的影响。方法 选取2016年10月～2017年10月来我院治疗的急性脑梗死患者100例，采用随机抽签法将其分为治 疗组与对照组各50例，对照组予以甲钴胺治疗，治疗组采用硫辛酸联合甲钴胺治疗，2周后评价治疗有效率，比较2 组治疗前后NHISS评分、血清超氧化物歧化酶(SOD)及血清丙二醛(MDA)水平。结果 治疗组有效率为90%，较对照组 高(P＜0.05)；治疗前后NHISS评分均有所下降，且治疗组较对照组下降幅度更大(P＜0.05)；2组患者治疗后血清 SOD及血清MDA水平均有下降，且治疗组下降更明显(P＜0.05)。结论 硫辛酸联合甲钴胺治疗急性脑梗死较单一使用 甲钴胺疗效更加确切，明显促进患者神经功能的恢复，改善机体氧化应激状态。

Objective To explore the efficacy of lipoic acid combined with mecobalamin in the treatment of acute cerebral infarction and its effects on the National Institutes of Health Stroke Scale (NHISS) score and oxidative stress level. Methods A total of 100 patients with acute cerebral infarction who were treated in our hospital from October 2016 to October 2017 were selected and divided into treatment group and control group according to the method of random sampling, with 50 cases in each group. Control group was given mecobalamin, and treatment group was given lipoic acid combined with mecobalamin. The effective rate of treatment was evaluated after 2 weeks. The NHISS score and levels of serum superoxide dismutase (SOD) and serum malondialdehyde (MDA) were compared between the two groups before and after treatment. Results The effective rate (90%) in treatment group was higher than that in control group (P<0.05). The NHISS scores were decreased after treatment, and the decrease in treatment group was greater than that in control group (P<0.05). The levels of serum SOD and serum MDA in the two groups were decreased after treatment, and the decreases were more significant in treatment group (P<0.05). Conclusion Lipoic acid combined with mecobalamin has more exact efficacy in the treatment of acute cerebral infarction than metocobalamine alone. And it can promote the recovery of neurological function and improve the body’s oxidative stress.