目的 研究纳洛酮在临床治疗中的量效关系。方法 选取2011年2月-2015年2月收治的100例脑梗死患者，随机分为四 组，每组25例，分别给予1.2mg、2.4mg、3.6mg、5.8mg剂量的纳洛酮进行治疗，以15d为一个疗程，观察观察一个 疗程后的疗效。结果 1.2mg组基本无效；2.4mg组处于量效关系的上升阶段；3.6mg组具有良好的治疗效果，但与 5.8mg之间无明显差异。结论 纳洛酮治疗脑梗死最佳剂量在3.6mg到5.8mg范围之内。

Objective To study dose effect relationship of Naloxone in the treatment of clinical treatment. Methods From February 2011 to February 2015, 100 patients with cerebral infarction were randomly divided into four groups, 25 cases each. 1.2mg, Mg, 2.4mg, Mg, 3.6mg, Mg and 5.8mg mg doses of naloxone were administered to each group of patients. 15 days as a course of treatment, and observe the curative effect after a course of treatment. Results The 1.2mg group is almost ineffective, the 2.4mg group was in the rising phase of dose effect relationship. The 3.6mg group has good curative effect, but there is no obvious difference between the 5.8mg group. Conclusion According to the analysis of the dose effect curve, from 3.6 mg to 5.8 mg within the scope of use of naloxone in the treatment of cerebral infarction and the optimal dose.