目的 观察左乙拉西坦治疗难治性癫痫疗效分析及对免疫功能的影响。方法 选择2013年2月至2016年2月我院收治 的难治性癫痫患者100例，按照随机数字表法分为对照组(n=50)和观察组(n=50)，对照组给予卡马西平，观察组给 予左乙拉西坦，比较两组患者临床疗效、免疫功能及不良反应。结果 观察组患者临床总有效率88.00%显著高于对 照组70.00%(P<0.05)；两组患者治疗后较治疗前CD4+、IgA、IgG水平均显著升高(P<0.05)，CD8+水平均显著降低 (P<0.05)；且观察组患者CD4+、IgA、IgG水平升高幅度及CD8+水平降低幅度均显著大于对照组(P<0.05)；观察组患 者不良反应发生率10.00%与对照组12.00%无显著差异(P>0.05)。结论 左乙拉西坦治疗难治性癫痫疗效显著，可以 提高患者免疫功能。

Objective To observe the curative effect of levetiracetam on intractable epilepsy and its influence on immune function. Methods From Feb. 2013 to Feb. 2016, 100 patients with intractable epilepsy in our hospital were randomly divided into control group (n=50) and observation group (n=50). The control group was given carbamazepine, and the observation group was given levetiracetam. The curative effects, immune function and adverse reactions in the two groups were compared. Results The total effective rate in the observation group was 88% which was significantly higher than that in the control group 70% (P<0.05), after treatment, the levels of CD4+, IgA and IgG in the two groups were significantly increased (P<0.05), but the CD8+ levels in the two groups were significantly decreased (P<0.05), the increase of CD4+, IgA, IgG and decrease of CD8+ in the observation group were all significantly higher than those in the control group (P<0.05), the incidence rate of adverse reactions in the observation group was 10% which was lower than that in the control group 12%, but their difference was not statistically significant (P>0.05). Conclusion Levetiracetam which is effective in the treatment of intractable epilepsy, can improve the immune function of patients.