目的 探讨不同剂量依托咪酯复合舒芬太尼应用于老年颅脑手术麻醉诱导中的效果。方法 选取我院2015年4月-2016 年3月收治的老年颅脑手术患者78例，以随机数字表法分为两组，每组39例，A组给予0.2mg/kg依托咪酯，B组给予 0.4mg/kg依托咪酯，均复合舒芬太尼0.5μg/kg进行麻醉诱导，记录两组患者不同时间的血流动力学变化。结果 A 组MAP在T2-T5时间点均低于B组，HR在T3-T5时间点低于B组，BIS在T3-T5时间点高于B组，差异均有统计学意义(P ＜0.05)；A组不良反应发生率为12.82%，B组为15.38%，两组对比无明显差异(P＞0.05)。结论 0.2mg/kg依托咪酯 复合舒芬太尼应用于老年颅脑手术麻醉诱导血流动力学更稳定。

Objective To probe into the effects of different doses of etomidate combined with sufentanil in application of induction of anesthesia in craniocerebral surgery in the elderly. Methods 78 cases of elderly patients with craniocerebral surgery and who accepted treatments in our hospital from April, 2015 to March, 2016 were selected as the research object,and were grouped by the random number table method, the group A of 39 cases and 39 cases in group B.The group A were given 0.2mg/kg etomidate,while the B group were given the 0.4mg/kg etomidate, and sufentanil 0.5 g/kg was added to induce anesthesia. Then, the hemodynamic changes at different times were recorded between two groups.Results The MAP at T2-T5 time point in the group A were lower than that in the group B, and the HR at T3-T5 time point were lower than that in the group B,and the BIS at the T3-T5 time point was higher than in the group B, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in group A was 12.82%, and that in group B was 15.38%. There was no significant difference between the two groups (P>0.05). Conclusion The 0.2mg/ kg etomidate combined with sufentanil for anesthesia induction in elderly patients undergoing craniocerebral surgery, which the safety are high, and can maintain the hemodynamic stability during operation and it is conducive to the smooth development of the operation.