目的 比较多乐氟与GC护牙素两种制剂在固定正畸治疗中的抑制釉质脱矿的临床疗效。方法 选择我院正畸科进行 固定矫治患者120例，共2526颗牙齿。参照随机数字表将患者分为三组：A组（40例，850颗）在治疗过程中使用GC 护牙素涂布牙齿表面，每月1次；B组（40例，896颗）使用多乐氟涂布，每3个月1次；C组（40例，780颗）作为空 白对照组，牙齿表面不做特殊处理。比较三组患者矫正后6个月的釉质脱矿情况。结果 矫正前三组患者均为出现3 度釉质脱落，且组间釉质脱落区数无显著差异（P>0.05），在矫正开始第6个月，三组釉质脱落区数存在显著差异 （P<0.001）；比较三组釉质脱矿指数，矫正前无显著差异（P>0.05），矫正6个月时三组较矫正前指数显著上升， 且A、B两组无显著差异，C组明显高于A、B两组（P<0.05）。结论 多乐氟和GC护牙素在固定正畸治疗中，均可有效 抑制牙釉质脱矿现象，临床可根据患者具体情况选择合适方案。

Objective To compare the clinical effect of Duraphat and GC tooth friendly paste in inhibiting enamel demineralization during fixed orthodontic treatment. Methods A total of 120 patients (2526 teeth) received orthodontic treatment in our hospital were selected in the study, which were divided into group A (40 cases, 850 teeth), group B (40 cases, 896 teeth) and group C (40 cases, 780 teeth) by random number table method. During treatment, patients of group A used GC tooth friendly paste to coat outer surface of teeth once per month, patients of group B used Duraphat to coat and group C was blank control group without special treatment. 6 months after correction, the status of enamel demineralization was compared among groups. Results There was grade 3 enamel demineralization in all groups before correction, the number of areas with enamel demineralization showed no significant difference among groups (P>0.05). In the sixth month after the beginning of correction, there were significant differences in the number of areas with enamel demineralization among groups (P<0.001). There was no significant difference in enamel demineralization index among groups before correction (P>0.05). In the sixth month after the beginning of correction, the index was increased significantly, there was no significant difference between group A and group B, it was higher in group C than group A and group B (P<0.05). Conclusion Both of Duraphat and GC tooth friendly paste can effectively inhibit enamel demineralization in fixed orthodontic treatment. The appropriate scheme can be chosen according to the actual condition.