目的 探讨血浆置换治疗慢性重型乙型肝炎的临床效果分析。方法 回顾性分析2010年1月-2016年10月在我院接受 治疗的慢性重型乙型肝炎患者181例，随机分为对照组85例和观察组96例，对照组给予常规的综合内科治疗，观察 组给予常规的综合内科治疗联合血浆置换的治疗方法，观察两组患者的肝肾功能、凝血指标，以及两组的治疗的 有效率。结果 对照组的治疗的好转率为82.35%，观察组治疗的好转率为93.75%，两组间的差异有统计学意义（P ＜0.05）；观察组的肝功能和凝血指标的改善情况均优于对照组，差异有统计学意义（P＜0.05）。结论 血浆置换 治疗慢性重型乙型肝炎不仅可以明显的改善患者的实验室指标，而且可以提高患者的治疗的好转率，具有良好的效 果，值得在临床中推广应用。

Objective To investigate the clinical effect of plasma exchange in the treatment of chronic severe hepatitis B. Methods 181 patients with chronic severe hepatitis B treated in our hospital from January 2010 to October 2016 were retrospectively analyzed. They were randomly divided into control group (n=85) and observation group (n=96). The control group received routine medical treatment , The observation group was treated with routine medical treatment combined with plasma exchange. The liver and kidney function, blood coagulation index and the effective rate of the two groups were observed. Results The improvement rate of the control group was 82.35%, the improvement rate of the observation group was 93.75%, the difference between the two groups was statistically significant (P <0.05); observation group liver function and coagulation improvement (P<0.05), and the difference was statistically significant (P<0.05). Conclusion Plasma exchange for chronic severe hepatitis B can not only improve the laboratory indexes of patients, but also improve the improvement rate of treatment. It has a good effect and is worth popularizing in clinic.