简体中文

·胸部疾病·

小剂量阿奇霉素对肺结核合并支气管扩张症治疗结果的影响

作者:易小莉

所属单位:广东省江门台山市中医院呼吸病科 (广东 江门 529200)

PDF

摘要

目的 探讨小剂量阿奇霉素对肺结核合并支气管扩张症治疗结果的影响。方法 选取2012年9月-2016年9月我院收治 的90例肺结核合并支气管扩张症患者,按照随机数表法,将所有患者分为两组,观察组与对照组各45例,观察组患 者在其急性后期给予口服小剂量阿奇霉素治疗6个月,对照组患者在其急性后期采取常规治疗,不给予阿奇霉素, 对比两组患者的治疗结果,主要比较其6个月内的再次就诊次数、血清超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC) 和肺功能等指标的改变情况。结果 观察组患者在治疗后6个月的再次就诊次数明显低于对照组,且其hs-CRP、WBC 及肺功能各项指标等改善情况明显优于对照组,组间对比差异显著,具有统计学意义,P<0.05。结论 给予肺结核 合并支气管扩张症患者长期服用小剂量阿奇霉素治疗,可显著减少其急性发作次数,有利于改善患者肺功能,值得 临床推广应用。

Objective To investigate the effect of low dose azithromycin on pulmonary tuberculosis complicated with bronchiectasis. Methods From September 2012 to September 2016, 90 patients with pulmonary tuberculosis and bronchiectasis were enrolled in our hospital. According to the random number table method, all patients were divided into two groups: observation group and control group, Patients in the acute late to oral low-dose azithromycin for 6 months, the control group of patients in the acute late to conventional treatment, not to give azithromycin, compared the two groups of patients with treatment results, the main comparison within 6 months of the number of retreatment, Serum high sensitive C-reactive protein (hs-CRP), white blood cell count (WBC) and lung function and other indicators of the changes. Results The number of re-treatment in the observation group was significantly lower than that in the control group at 6 months after treatment, and the improvement of hs-CRP, WBC and lung function were better than those of the control group, the difference was significant Statistical significance, P <0.05. Conclusion Long-term administration of low - dose azithromycin in patients with pulmonary tuberculosis complicated with bronchiectasis can significantly reduce the number of acute exacerbations and improve pulmonary function in patients with pulmonary tuberculosis, which is worthy of popularization and application.

【关键词】小剂量;阿奇霉素;肺结核合并支气管扩张症;治疗结果

【中图分类号】R521

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2017.03.011

前言

肺结核在我国属于高发病,目前,支气管扩张症 也十分常见,且缺乏有效的治疗手段,支气管扩张症 (BE)是临床上常见的呼吸系统疾病,其发病机制尚未 明确[1]。为了解小剂量阿奇霉素对肺结核合并支气管 扩张症治疗结果的影响,本次研究对我院于2012年9 月-2016年9月期间收治的90例肺结核合并支气管扩张 症患者采取了相关治疗,其中在急性期应用小剂量阿 奇霉素治疗的观察组获得了满意疗效,现将详情报道 如下。