简体中文

·头颈疾病·

布地奈德鼻喷雾剂联合盐酸氮卓斯汀片治疗变应性鼻炎的临床 研究

作者:倪 力

所属单位:广东省佛山市南海区第四人民医院 (广东 佛山 528200)

PDF

摘要

目的 探究布地奈德鼻喷雾剂联合盐酸氮卓斯汀片治疗变异性鼻炎的临床效果。方法 选取我院2014年6月到2015年 12月间收治的变应性鼻炎患者100例,采用随机数字法分为观察组(50例)和对照组(50例),对照组患者给予盐酸氮 卓斯汀片进行治疗,观察组在此基础上联合用布地奈德鼻喷雾剂治疗,治疗一个疗程后比较两组患者的治疗有效 率,同时比较治疗前后两组患者的喷嚏、流涕、鼻塞、鼻痒等症状评分。结果 观察组患者的治疗有效率明显高于 对照组(P<0.05),同时观察组患者治疗后喷嚏、流涕、鼻塞、鼻痒等症状评分明显低于对照组(P<0.05)。结论 布地奈德鼻喷雾剂联合盐酸氮卓斯汀片治疗变应性鼻炎的具有明显疗效,能有效提高临床治疗变应性鼻炎的有效 率,改善各种变应性鼻炎的临床症状,是一种安全高效的治疗方案,值得在临床中推广使用。

Objective To explore the clinical effect of treatment of allergic rhinitis with Budesonide Nasal Spray Azelastine Hydrochloride Tablets. Methods 100 patients with allergic rhinitis in our hospital from June 2014 to December 2015 were divided into observation group randomly (50 cases) and control group (50 cases),the control group were treated with Azelastine Hydrochloride Tablets for treatment, observation combined with Budesonide Nasal Spray group based on the treatment, after a course of treatment, compare two groups of patients with treatment efficiency, and compare the treatment of the two groups of patients before and after sneezing, runny nose, nasal congestion, nasal itching and other symptoms score. Results To observe the treatment group the effective rate was significantly higher than that of the control group (P<0.05), and to observe the patients in the treatment group after sneezing, runny nose,nasal congestion, nasal itching and other symptoms score was significantly lower than that of the control group (P<0.05). Conclusion Budesonide nasal spray hydrochloride combined with nitrogen Azelastine for treatment of allergic rhinitis has obvious curative effect, can effectively improve the clinical treatment of allergic rhinitis efficiency, improve the clinical symptoms of all kinds of allergic rhinitis is a safe and efficient treatment. It is worth in clinical application.

【关键词】布地奈德鼻喷雾剂;氮卓斯汀片;变应性鼻炎

【中图分类号】R765.21

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2016.05.002

前言

变应性鼻炎又称过敏性鼻炎,是指过敏性体质的 个体在接触特异性抗原后引起的一种鼻黏膜非感染 性炎性疾病,包括有IgE介导的介质(主要是组胺)释 放和多种免疫活性细胞以及细胞因子等的参与[1]。其 发生的必要条件有3个:特异性抗原即引起机体免疫 反应的物质;特应性个体即所谓个体差异、过敏体 质;特异性抗原与特应型个体二者相遇[2]。其临床表 现有阵发性喷嚏、清水样鼻涕、鼻塞和鼻痒等并伴有 嗅觉减退。严重患者可导致许多疾病甚至造成劳动力丧失,变应性鼻炎是一个全球性健康问题。布地奈德 鼻喷雾剂与氮卓斯汀片作为临床上治疗变应性鼻炎的 两种药物,目前临床大量研究显示,两种药物治疗变 应性鼻炎均疗效明显,但临床上尚比较少联合使用报 告,今为进一步研究两种药物联合使用的疗效,选取 100例患者进行研究,现将具体报告如下。