目的 探讨围急性呼吸窘迫综合征患者血清Clara细胞分泌的特异性蛋白-CC16蛋白水平的预警意义。方法 回顾性分 析我院从2013年3月到2014年3月入院治疗的60例急性呼吸窘迫综合症患者(将其定义为观察组)的临床资料。另选 取我院同期参加健康体检的健康成年人58例的临床资料为对照组。将观察组患者病情进展过程中不同时期血清中 Clara细胞分泌的特异性蛋白-CC16蛋白水平与对照组健康人群指标进行比较，评估其临床预警意义。结果 观察组 患者各时期血清CC16蛋白水平均高于对照组，随着病情的进展，血清CC16蛋白水平持续增高，前三个阶段血清CC16 蛋白水平呈逐级递增趋势，差异具统计学意义(P＜0.05)，临终期与ARDS期血清CC16蛋白水平接近，差异无统计学 意义(P＞0.05)。结论 急性呼吸窘迫综合征患者血清Clara细胞分泌蛋白CC16水平在患者炎症反应初期即开始升 高，且变化早于血气分析指标的变化，故可将CC16指标变化情况用于早期急性呼吸窘迫综合征的诊治及预后评估， 值得临床广泛推广应用。

Objective To explore the warning significance of serum Clara cell secretory protein levels of specific proteins -CC16 in acute respiratory distress syndrome. Methods A retrospective analysis of our hospital from March 2013 to March 2014 hospitalization of 60 patients with acute respiratory distress syndrome, which is defined as the observation group) clinical data. Also participating in the same period in our hospital healthy adults 58 cases of clinical data for the control group. The progress of the disease observed in patients during different periods of serum Clara cell secretory protein -CC16 specific protein levels were relatively healthy population indicators to evaluate the clinical significance of early warning. Results The serum CC16 protein levels were higher in each period, as the disease progresses, serum CC16 protein levels continued to increase, the first three stages of serum CC16 protein levels showed gradual increasing trend, the difference statistically significant (P<0.05), and dying of ARDS CC16 serum levels of close, the difference was not statistically significant (P>0.05). Conclusion Acute respiratory distress syndrome serum Clara cell secretory protein CC16 levels began to increase in patients with early inflammatory response, and the change earlier than changes in blood gas analysis, so the changes can be CC16 indicators for early acute respiratory distress syndrome Diagnosis, treatment and prognosis, worthy of wider application.