目的 探讨学龄期哮喘患儿治疗前后血清基质金属蛋白酶组织抑制因子-1(TIMP-1)、白细胞介素-10(IL-10)、高敏C 反应蛋白(hs-CRP)及甲状腺素(TH)水平变化及其临床意义。方法 选取自2013年2月至2015年1月于我院儿科就诊并 接受治疗的支气管哮喘患儿126例，并与55例正常儿童进行对照，比较两组儿童血清TIMP-1、IL-10、hs-CRP及TH水 平。结果 哮喘组患儿治疗前后血清TIMP-1、IL-10、hs-CRP及TH水平均有明显差异，且均较正常对照组存在显著异 常(P<0.05)；哮喘发作期血清血清TIMP-1、IL-10、hs-CRP水平均显著高于缓解期(P<0.05)。结论 联合检测血清 TIMP-1、IL-10、hs-CRP和TH水平，有助于哮喘的诊断和鉴别疾病的不同阶段。

Objective To investigate the changes of serum TIMP-1, IL-10, hs-CRP and TH in school-age children with asthma before and after treatment. Methods 126 children with asthma were collected, compared with 55 cases of healthy children. The level of serum TIMP-1, IL-10, hs-CRP and TH were compared respectively. Results Serum levels of TIMP-1, IL-10, hs-CRP and TH were significantly different before and after treatment and both had significant abnormalities than the control group in the asthma group(P<0.05). Serum levels of TIMP-1, IL-10, hs-CRP were significantly higher in attack than remission(P<0.05). Conclusion Combined detection of serum TIMP-1, IL-10, hsCRP and TH levels, contribute to the diagnosis of asthma and identification of different stages of this disease.